Desert Five-spot (Eremalche rotundifolia), is a flowering plant in the family Malvaceae, native to the Sonoran and Mojave Desert in the southwestern United States, where it is found between 50 and 1,500 meter altitude, most frequently in sandy and rocky washes and usually in gravelly alkaline soils.

It can be found in Anza-Borrego Desert State Park and in Death Valley National Park in southern California. It is an annual plant growing to 8-60 centimeter tall, with rounded leaves 1.5-6 centimeter broad with a toothed margin. The flowers are beautiful rose-pink to lilac with five petals, each with a dark red spot at the base. The flowers close up at night and open back up again in the morning.

Plant Desert Fivespot in fast draining alkaline soil. It apparently does not grow well in containers.

This plant should not be confused with the non-desert Fivespot (Nemophila maculata), which is white with purple spots, grows in the Sierra mountains and is often included wildflower mixes.